News & Events


YAM Laboratory

2022


Congratulations to Samuel for receiving the Poster Presentation Award in the annual Research Postgraduate Symposium, LKS Faculty of Medicine, HKU. Keep up the good work! Well done!
December 2022

Samuel is going to present his work on the second day of Research Postgraduate Symposium. Cherlie is the Chairperson of the organizing committee. Thank you for the hard work.
December 2022

Cherlie presented her latest work at the State Key Laboratory of Liver Research Tripartite Joint Forum (滬港(兩地三方)肝病高峰論壇).
November 2022

Our study is featured as one of the HKU’s cancer-fighting research at HKU website.
October 2022

Samuel presented the study of EV-pIgR at today’s State Key Laboratory of Liver Research (HKU) Symposium. A well spent Saturday at an informative and interactive meeting.
October 2022

Our PhD students, Zhixian, Cherlie and Samuel participated in the Annual Scientific Meeting of Hong Kong Society of Flow Cytometry. Thank you for their effort in the preparation of poster and presentation. They all did a good job! Congratulations to Cherlie for winning the Best Poster Award!
October 2022

Samuel, our PhD student, is going to share the study of pIgR-enriched small extracellular vesicles in liver cancer stemness and metastasis at the upcoming State Key Laboratory of Liver Research Symposium on October 29, 2022. Stay tuned!
October 2022

This is a new review article written by our PhD student Zhixian. The paper describes the recent advancement in using circulating tumor cells, exosomes and cell-free nucleic acids as biomarkers of cancer. Well done Zhixian!
August 2022

https://onlinelibrary.wiley.com/doi/10.1002/ctd2.111


Our PhD student Samuel shared his research findings at the annual internal research meeting of State Key Laboratory of Liver Research . Congratulations to Samuel for obtaining the Best Oral Presentation Award. Proud of you!
August 2022

MPhil student Tingmao published his first paper about the functional roles of small extracellular vesicles in liver diseases. Well done!
August 2022

https://www.xiahepublishing.com/2310-8819/JCTH-2022-00008


Five students from local and UK secondary schools joined our lab as summer interns.
They are able to master some technical skills and have a chance to get involved in research projects.
We hope their lab experience can foster their interest in conducting research.
June-August 2022

Samuel, our PhD student, gave an oral presentation about his study on EV-vWF at the Departmental Research Postgraduate Students Retreat. Our congratulations to Samuel for getting the Most Innovative Award!
July 2022

Our PhD students Zhixian, Samuel and Cherlie presented their posters in the 2022 Hong Kong Inter-University Postgraduate Symposium in Life Science. What a fun, enjoyable and interactive way using the Virbela virtual platform!
We look forward to next years’ participation.

June 2022

Xu Yi was selected as one of the oral presenters to give a talk on his research project at the Hong Kong Scholars Annual Symposium. It was an interactive meeting with all Hong Kong Scholars of different disciplines. Xu Yi gave an excellent presentation and obtained the Best Oral Presentation Award. Congratulations!!!
June 2022

In collaboration with Department of Microbiology HKU, we have extended our work on extracellular vesicles
in the area of infectious disease.  This study reveals the role of ACE2 receptor localized on the surface of small extracellular vesicles in enhancing the entry of SARS-CoV-2 into the host cells.
We thank Dr Kelvin To’s group for performing the infectivity assay using SARS-CoV-2 live virus.
May 2022

https://onlinelibrary.wiley.com/doi/10.1002/jev2.12231


This collaborative study with Professor Gao of Southern Medical University is now published online. The work is mainly conducted by Professor Gao’s student, Xiaomei, who attached to our lab last year. Thank you Sze Keong for supervising Xiaomei and team members for assistance in the study. Well done Xiaomei!
May 2022

https://link.springer.com/article/10.1007/s12072-022-10338-3


This is a continual study of our previous work on nuclear Met receptor. This study reveals how nuclear Met provokes liver cancer metastasis by the release of extracellular vesicles enriched with translation regulatory proteins.
May 2022

https://onlinelibrary.wiley.com/doi/10.1002/jex2.39


Please read this comprehensive review written by Cherlie. The figures are nicely drawn. Well done Cherlie!
February 2022

https://www.sciencedirect.com/science/article/abs/pii/S1044579X22000402?via%3Dihub


Coverage of our study on patient-derived polymeric immunoglobulin receptor-enriched extracellular vesicles
in HKUMed press release.
January 2022

http://www.med.hku.hk/en/news/press/20220126-ev-pigr-and-liver-cancer

http://www.med.hku.hk/zh-hk/news/press/20220126-ev-pigr-and-liver-cancer

https://www.hku.hk/press/news_detail_23986.html

https://www.hku.hk/press/c_news_detail_23986.html


This study demonstrated the functional role of pIgR carried by extracellular vesicles in promoting cancer stemness, tumor development and metastasis in hepatocellular carcinoma. The level of pIgR is elevated in circulating extracellular vesicles of liver cancer patients, and reduced in patients after surgery. From the clinical perspective, pIgR is a potential non-invasive biomarker and therapeutic target of liver cancer.
January 2022

https://www.journal-of-hepatology.eu/article/S0168-8278(21)02245-5/fulltext


2021


Goodbye 2021.
This has been a challenging yet fruitful year. Thank you my amazing team who is committed and dedicated to our research work. There are difficulties and failures along the way, but we will persevere, strive and solve each problem ahead. 2022- we are ready for a fulfilling and meaningful year!

December 2021

Congratulations on your graduation Janice!
We are delighted to see you again and thank you for those delicious cakes!
December 2021.

Congratulations on your graduation Nansen!
December 2021

Our MPhil student Cherlie presented her poster at the SKLLR/TRS Internal Meeting. It’s always eye-opening to learn from other teams who also work on liver cancer research. A Saturday morning well-spent!
December 2021.

Our PhD student Samuel and MPhil student Cherlie presented their posters at the 26th RPG Symposium. A stimulating 2-day event full of new ideas and inspiring discussions. Thank you for their hard work in preparing the presentation. Both did a very good job! Cheers on Cherlie for winning the poster presentation award!
December 2021

A heartfelt farewell to our PDF Sze Keong! We are truly thankful for your contribution throughout the past decade. All the best for your future endeavour in Singapore.
October 2021

Our summer intern, Tiffany and Joivia. Hope you enjoyed working in the lab. August 2021

Invitation by the Department of Ophthalmology, HKU to give a talk on grantsmanship for the preparation of GRF application. I am looking forward to this rewarding visit.

August 2021


Our latest study is now published online. This study revealed the deregulation of Rab20 in HCC cells resulted in the release of EVs with reduced level of TPI-1. The outcome of this study provides a mechanistic link between tumor cell-derived EVs and glucose metabolism in liver cancer. Congratulations to Bonnie! Thank you for the contributions of other team members.
August 2021

Click to read: https://onlinelibrary.wiley.com/doi/10.1002/jev2.12135


Tiffany joined the HKU 2021 Summer Research Programme and conducted a research project in our lab. She was awarded the conditional offer of the HKU Presidential PhD Scholar Programme for her outstanding performance. Congratulations to Tiffany!
August 2021

Our MPhil student Cherlie shared her project in the Departmental Research Postgraduate Retreat and was awarded the Best Presentation Award. Very well done!
It was the first department retreat since the outbreak of COVID-19……
A great reminder to never take little things for granted and cherish every opportunity to participate in scientific discussion. July 2021

Congratulations on Susan for her promotion as Research Assistant Professor!
July 2021

This year we held our annual retreat at HKSTP InnoCell, in collaboration with Dr. Maria Wong’s team. An inciting day of learning outside the lab. We shared our latest working progress and ended the night with a delicious BBQ dinner.
Fun and laughter overloaded!
June 2021

Our PhD student Samuel and MPhil student Cherlie presented their posters virtually at the 2021 Hong Kong Inter-University Symposium in Biomedical Sciences. A stimulating day of knowledge exchange amongst the three universities. Cheers to Cherlie on winning the Best Poster Presentation Award.
Look forward to sharing our interesting research findings face-to-face next year.
June 2021

The upcoming annual State Key Laboratory of Liver Research Symposium at The Park Lane Hotel, Hong Kong. Stay Tuned!
June 2021.

The study of Angel’s PhD project is recently published in Cancer Research journal.
Congratulations to Angel and thank you our team members for their effort in completing the study.
June 2021

Click to read : https://cancerres.aacrjournals.org/content/early/2021/05/10/0008-5472.CAN-20-3944


It has been an eye-opening experience for our PhD student Samuel and MPhil student Cherlie to share their recent work at the liver week 2021. Although we cannot travel to Korea in person this year, we are thrilled to learn from international researchers via virtual conference.
Congratulations to both of them for winning the Foreign Investigator Award.
May 2021.

Our warmest welcome to Dr. Xu, Yi , who joined our team through the Hong Kong Scholars Program.
Dr. Xu introduced his hometown Harbin and shared his research experience to our lab members.
It’s always inspiring to establish new research connections!
January 2021

Thank you all for the present, beautiful hand-drawn birthday card and delicious Lady M cake.
January 2021

2020


Although no party this year, the festive decoration has created the perfect Christmas atmosphere in lab. We are grateful to receive the gift of love and happiness from our Secret Santa. Merry Christmas! December 2020

Congratulations to Cherlie for receiving the Best Poster Presentation Award at the 25th RPG Symposium.
Well done!
December 2020

Our work about the function of EVs in protecting liver tumor cells from complement-mediated attack is published in the Journal of Extracellular Vesicles. Congratulations to Susan, Longyin and the team. Let’s keep up the good work.
November 2020

Click to read: https://onlinelibrary.wiley.com/doi/full/10.1002/jev2.12031


Susan presented at the internal meeting of State Key Laboratory of Liver Research (HKU) & Theme-Based Research Scheme Project on Liver Cancer Stemness.
November 2020

Invitation by the Department of Chemical Pathology, CUHK to give a talk about our recent work on extracellular vesicles.
November 2020

A brand new start! Our laboratory relocates to Block T 09-28.
There were lots of discoveries, laughter and hard work back in our old lab.
09-23, you will be missed!
May we continue this dedicated spirit in the new laboratory.
September 2020

We are deeply honoured to have our study being covered in the faculty news release and various media.
August 2020

http://www.med.hku.hk/en/news/press/20200831-ev-nid1-and-liver-cancer


Our first paper about extracellular vesicles. Thank you for the hard work of Susan, Sze Keong and Cherlie, and the concerted efforts of all collaborators.
August 2020

Click to read: https://doi.org/10.1002/advs.202002157


Congratulations to Angel who has passed the oral examination.
August 2020

Bonnie has passed oral examination. Congratulations Dr Liu.
June 2020

Bonnie presented her PhD project about the role of Rab20 in the regulation of exosomal content in EACR-AACR conference on tumor microenvironment at Portugal.
March 2020

March 2020

2019

Invited to present our work on EV in the annual meeting of the Asian Pacific Societies for Extracellular Vesicles at Jeju Island, Korea 🇰🇷 I am glad to know researchers working in the same field.
November 2019

Zoe published her work in Journal of Experimental & Clinical Cancer Research 😀 Congrats!
October 2019

Samuel obtained his degree with distinction. Well done! Thank you Samuel for treating our team to dinner 😛
September 2019

Cherlie, Bella and Samuel completed their MMedSc study 🙂
Well done!
August 2019

Sze Keong presented his work in the annual meeting of International Society of Extracellular Vesicles at Kyoto, Japan
April 2019

Susan completed her second project on Cav1 and got it published in Cancer Letters 😀 Well done!
March 2019

Visited my PhD supervisor, Professor Hsiao at CNY 🧧 She doesn’t age 😲
February 2019

Invited to present our study about the functional role and clinical implications of exosomes in liver cancer on the first day on Pathology 100th Anniversary & 7th Hong Kong Pathology Forum.
January 2019

Celebration for my birthday. Thank you all 😍
January 2019

2018

Angel was awarded the Best Poster Presentation Award in the Research Postgraduate Symposium 🙂 Congratulations!
December 2018

Grand opening of our laboratory at Block T, Queen Mary Hospital. Yeah!!! The roast suckling pig 🐷 is really good 😛
June 2018

March 2018

2017

Sze Keong published his PhD study on nuclear Met in Cancer Letters 😀 Congratulations!
December 2017

It’s challenging to give a talk on molecular biology to primary student at St. Stephen’s College Preparatory School 📚
December 2017

2016

Susan continued to work on Sivia’s MPhil study and published the work on Caveolin-1 in Cancer Research 😀 Thank you all for the hard work 😀
December 2016

Received 15 years Long Service Award 😉 Time flies 😅
June 2016

2015


Invited to give a talk on “The current understanding of DLC1 tumor suppressor in liver cancer” in the Department of Chemical Pathology, CUHK.
March 2015

Before 2014

Sze Keong obtained the Best Presentation Award in the Research Postgraduate Symposium 👍 Congratulations!
December 2014

Frankie published a review article on the regulation of DLC1 in International Journal of Cancer 😀
October 2013

This is the second paper about the regulation of DLC1 by kinase phosphorylation. It is published in Nature Communications 😀 Thank you Frankie and the team for their hard work.
March 2013

This a collaborative study on DLC1 and tensin2 with Dr. Zhu Guang of HKUST 😀
July 2012

Edith published her PhD findings on Caveolin-1 in Journal of Pathology 😀 Good job 👍
March 2012

This the first study to show the deregulation of DLC1 by Akt phosphorylation leading to liver cancer development and metastasis published in Gastroenterology 😀
October 2010

I am deeply honored to receive the Outstanding Young Researcher Award 2008-2009. I appreciate the support from my mentors and research team members 🙂
January 2010