YAM Laboratory

#Co-first author; *Corresponding author


  • Research articles
  • Chen L, Chen Z, Zhang X, Tey SK, Xia ZY, Lee TKW, Yam JWP, Mao XW*. Propofol inhibition of hepatocellular carcinoma via the prevention of reactive oxygen species-induced Cav1 and HO-1 activation. (Under review)
  • Xiao ZJ*, Wang SQ, Tin VPC, Jiang Y, Wong MP, Pan Y, Yam JWP. The dual role of NFATc2/galectin-9 axis in modulating tumor initiating cell phenotypes and immune suppression of lung adenocarcinoma. (Under review)
  • Yao Y#, Xu Y#, Liang Y, Xiao ZJ, Tin PC, Fung HL, Ma HT, Yun JP, Yam JWP*. NHE7 upregulation potentiates the uptake of small extracellular vesicles by macropinocytosis in hepatocellular carcinoma. Cancer Communications (Under revision)
  • Xu Y#*, Yao Y#, Liang Y#, Zhang X, Mao XW, Tey SK, Wong SWK, Yeung CLS, Ng TM, Wong MYM, Che CM, Lee TKW, Gao Y, Cui Y, Yam JWP*. Clathrin light chain A-enriched small extracellular vesicles remodel microvascular niche to induce hepatocellular carcinoma metastasis. Journal of Extracellular Vesicles 2023, 12(8):e12359.
  • Wong SWK, Tey SK, Mao XW, Fung HL, Xiao ZJ, Wong DKH, Mak LY, Yuen MF, Ng IOL, Yun JP, Gao Y, Yam JWP*. Small extracellular vesicle-derived vWF induces a positive feedback loop between tumour and endothelial cells to promote angiogenesis and metastasis in hepatocellular carcinoma. Advanced Science 2023, 30:e2302677.
  • Xu Y#, Yao Y#, Liang Y#, Fung HL, Tang AHN, Ng IOL, Wong MYM, Che CM, Yun JP, Cui Y, Yam JWP*. Clathrin light chain A facilitates small extracellular vesicles uptake to promote hepatocellular carcinoma progression. Hepatology International 2023, doi: 10.1007/s12072-023-10562-5
  • Ruan ML, Liu Y, Zhang C, Mao XW, Hu D, Lok CN*, Yam JWP, Che CM*. Dihydroartemisinin engages liver fatty acid binding protein and suppresses metastatic hepatocellular carcinoma growth. Chemical Communications (Camb) 2023, 59(19):2747-2750.
  • Wang X, Huang H, Sze KMF, Wang J, Tian L, Lu J, Tsui YM, Chung CYS, Ma HT, Lee E, Chen A, Lee JMF, Wang Y, Yam JWP, Cheung TT, Guan XY, Ng IOL*. S100A10 promotes HCC via extracellular vesicles and regulating their protein cargos. Gut 2023, 72(7):1370-1384.
  • Wang SQ, Chen JJ, Yam JWP, Wong MP*, Xiao ZJ*. Targeting GSTP1 as therapeutic strategy against lung adenocarcinoma stemness and resistance to tyrosine kinase inhibitors. Advanced Science 2023, 10(7):e2205262.
  • Review
  • Chen Z, Yam JWP, MaoXW*. The multifaceted roles of small extracellular vesicles in metabolic reprogramming in the tumor microenvironments. (Under review)
  • Lee KW, Yam JWP, Mao XW*. Dendritic cell vaccines: A shift from conventional approach to new generations. Cells 2023, 12(17):2147.
  • Zhao X, Wang Y, Xia H, Liu S, Huang Z, He R, Yu L, Meng N, Wang H, You J, Li J, Yam JWP*, Xu Y*, Cui Y* Roles and molecular mechanisms of biomarkers in hepatocellular carcinoma with microvascular invasion: A review. Journal of Clinical and Translational Hepatology 2023, 11(5):1170-1183.
  • He R#, Xu Y#, Yu L, Meng N, Wang H, Cui Y*, Yam JWP*. Extracellular vesicles act as carriers for cargo delivery and regulate Wnt signaling in hepatocellular carcinoma tumor microenvironment. Cancers 2023, 15(7):2088.
  • Lau NCH, Yam JWP*. From exosome biogenesis to absorption: Key takeaways for cancer research. Cancers 2023, 15(7):1992.
  • Huang Z#, Xia H#, Cui Y, Yam JWP*, Xu Y*. Ferroptosis: From basic research to clinical therapeutics in hepatocellular carcinoma Journal of Clinical and Translational Hepatology 2023, 11(1):207-218.
  • Tey SK, Yam JWP*. The importance of activated TMPRSS2 in proviral role of extracellular vesicles in SARS-CoV-2 infection. Journal of Extracellular Vesicles 2023, 11(12):e12296.


  • Research articles
  • Tey SK, Lam H, Wong SWK, Zhao H, To KKW*, Yam JWP*. ACE2-enriched extracellular vesicles enhance infectivity of live SARS-CoV-2 virus in an endocytosis-dependent manner. Journal of Extracellular Vesicles 2022, 11(5):e12231.
  • Mei P, Tey SK, Wong SWK, Ng TH, Mao XW, Yeung CLS, Xu Y, Yu L, Huang Q, Cao P, Yam JWP*, Gao Y*. Actin Related Protein 2/3 Complex Subunit 2-enriched extracellular vesicles drive liver cancer metastasis. Hepatology International 2022, 16(3):603-613.
  • Tey SK, Wong SWK, Yeung CLS, Li JYK, Mao XW, Chung CYS, Yam JWP*. Liver cancer cells with nuclear MET overexpression release translation regulatory protein-enriched extracellular vesicles exhibit metastasis promoting activity. Journal of Extracellular Biology 2022, 1:e39.
  • Tey SK#, Wong SWK#, Chan JYT, Mao XW, Ng TH, Yeung CLS, Leung Z, Fung HL, Tang AHN, Wong DKH, Mak LY, Yuen MF, Sin CF, Ng IOL, Ma SKY, Lee TKW, Cao PH, Zhong K, Gao Y, Yun JP, Yam JWP*. Patient pIgR-enriched extracellular vesicles drive cancer stemness, tumorigenesis and metastasis in hepatocellular carcinoma. Journal of Hepatology 2022, 76(4): 883-895.
    • With editorial: Zingoni A, Banales JM. PIGR-enriched circulating vesicles contributes to hepatocellular carcinoma aggressiveness. Journal of Hepatology 2022, 76(4):768-770.
  • Review
  • Yeung CLS, Yam JWP*. Therapy-induced modulation of extracellular vesicles in hepatocellular carcinoma. Seminars in Cancer Biology 2022, 86:1088-1101.
  • Xiao XJ, Yeung CLS, Yam JWP, Mao XW*. An update in the role of complement in hepatocellular carcinoma. Frontiers in Immunology 2022, 13:1007382.
  • Huang Z, Xia H, Cui Y, Yam JWP*, Xu Y*. Ferroptosis: From basic research to clinical therapeutics in hepatocellular carcinoma Journal of Clinical and Translational Hepatology 2022, 11(1):207-218.
  • Xue T, Yam JWP*. Role of extracellular vesicles in liver diseases: Pathogenesis, diagnosis and treatments. Journal of Clinical and Translational Hepatology 2022, 10(6):1176-1185.
  • Chen Z, Yam JWP*. Recent advances in liquid biopsy in cancers: Diagnosis, disease stage and treatment response monitoring. Clinical and Translational Discovery 2022, 2:e111.
  • Xia H, Huang Z, Wang Z, Liu S, Zhao X, You J, Xu Y*, Yam JWP*, Cui Y*. Glucometabolic reprogramming: From trigger to therapeutic target in hepatocellular carcinoma. Frontiers in Oncology 2022, 12:953668.
  • Xia H, Huang Z, Cui Y*, Yam JWP*, Xu Y*. Reprogramming of central carbon metabolism in hepatocellular carcinoma. Biomedicine & Pharmacotherapy 2022, 153:113485.
  • Zheng W, Bai X, Zhou Y, Yu L, Zheng Y, Meng N, Wang H, Huang Z, Chen W, Yam JWP*, Xu Y*, Cui Y*. Transcriptional ITPR3 as potential targets and biomarkers for human pancreatic cancer. Aging (Albany NY) 2022, 14(10):4425-4444.


  • Research articles
  • Liu BHM, Tey SK, Mao XW, Ma APY, Yeung CLS, Wong SWK, Ng TH, Xu Y, Yao Y, Fung EYM, Tan KV, Khong PL, Ho DWH, Ng IOL, Tang AHN, Cai SH, Yun JP, Yam JWP*. TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis. Journal of Extracellular Vesicles 2021, 10:e12135.
  • Ma APY, Yeung CLS, Tey SK, Mao XW, Wong SWK, Hg, TH, Ko FCF, Kwong EML, Tang AHN, Ng IOL, Cai SH, Yun JP, Yam JWP*. Suppression of ACADM-mediated fatty acid oxidation promotes hepatocellular carcinoma via aberrant Cav1/SREBP-1 signaling. Cancer Research 2021, 81:3679-3692.
  • Qu X, Leung TCN, Ngai SM, Tsai SH, Thakur A, Li WK, Lee Y, Leung L, Ng TH, Yam JWP, Lan L, Lau EHL, Wong EWY, Chan JYK, Meehan K*. Proteomic analysis of circulating extracellular vesicles identifies potential biomarkers for lymph node metastasis in oral tongue squamous cell carcinoma. Cells 2021, 10(9):2179.
  • Leung L, Lau N, Liu J, Qu X, Tsui SKW, Hou J, Law CTY, Ng TH, Yam JWP, Chow C, Chan ABW, Chan JYK, Meehan K*. The role of arginine metabolism in oral tongue squamous cell carcinoma. Cancers 2021, 13(23):6068
  • Review
  • Zheng WY, Ji DL, Zhou YX, Yu L, Huang P, Zheng YL, Meng NF, Wang H, Bai X, Huang ZY, Chen WM, Yam JWP*, Xu Y*, Cui YF*. Exosomal non-coding RNAs in hepatobiliary cancer: A rising star. Molecular Cancer Therapeutics 2021, 20:1777-1788.
  • Huang ZY Xia H, Liu S, Zhao X, He R, Wang Z, Shi W, Chen W, Kang P, Su Z, Cui Y*, Yam JWP*, Xu Y*. The mechanism and clinical significance of circular RNAs in hepatocellular carcinoma. Frontiers in Oncology 2021, 11:714665.
  • Xia H, Huang Z, Liu S, Zhoa X, He R, Wang Z, Shi W, Chen W, Li Z, Yu L, Huang P, Kang P, Su Z, Xu Y*, Yam JWP*, Cui Y*. LncRNA DiGeorge Syndrome Critical Region Gene 5: A crucial regulator in malignant tumors. Biomedicine & Pharmacotherapy 2021, 141:111889.
  • Liu B, Zhao N, Zhou YS, Lu YX, Chen WM, Huang ZY, Wang DS, Xu Y*, Yam JWP*, Cui Y*. Circular RNA circ_ABCB10 in cancer. Clinica Chimica Acta 2021, 518:93-100.
  • Xia H, Huang Z, Liu S, Zhao X, He R, Wang Z, Shi W, Chen W, Li Z, Yu L, Huang P, Kang P, Su Z, Xu Y*, Yam JWP*, Cui Y*. Exosomal non-coding RNAs: Regulatory and therapeutic target of hepatocellular carcinoma. Frontiers in Oncology 2021, 11:653846.
  • He R, Wang Z, Shi W, Yu L, Xia H, Huang Z, Liu S, Zhao X, Xu Y*, Yam JWP*, Cui Y*. Exosomes in hepatocellular carcinoma microenvironment and their potential clinical application value. Biomedicine & Pharmacotherapy 2021, 138:111529.


  • Mao XW#, Zhou LY#, Tey SK, Ma APY, Yeung CLS, Ng TH, Wong SWK, Liu BHM, Fung YME, Patz EF, Cao PH, Gao Y, Yam JWP*. Tumor extracellular vesicle-derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement-dependent cytotoxicity of tumor cells. Journal of Extracellular Vesicles 2020, 10(1): e12031.
  • Mao XW#, Tey SK#, Yeung CLS, Kwong EML, Fung YME, Chung CYS, Mak LY, Wong DKH, Yuen MF, Ho JCM, Pang H, Wong MP, Leung CON, Lee TKW, Ma V, Cho WCS, Cao PH, Xu X, Gao Y, Yam JWP*. Nidogen 1-enriched extracellular vesicles facilitate extrahepatic metastasis of liver cancer by activating pulmonary fibroblasts to secrete tumor necrosis factor receptor 1. Advanced Science 2020, 7(21): 2002157.
  • Wang SQ, Liu J, Qin J, Zhu Y, Tin V, Yam JWP, Wong MP, Xiao ZJ*. CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation. Cell Death & Disease 2020, 11: 410.

2011-2019 (Selected)

  • Leung Z, Ko FCF, Tey SK, Kwong EML, Mao XW, Liu BMH, Ma APY, Fung YMF, Che CM, Wong DKH, Lai CL, Ng IOL, Yam JWP*. Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells. Journal of Experimental & Clinical Cancer Research 2019, 38: 423.
  • Mao XW, Tey SK, Ko FCF, Kwong EML, Gao Y, Ng IOL, Cheung ST, Guan XY, Yam JWP*. C-terminal truncated HBx protein activates caveolin-1/LRP6/beta-catenin/FRMD5 axis in promoting hepatocarcinogenesis. Cancer Letters 2019, 444: 60-69.
  • Tey SK, Tse EYT, Mao XW, Ko ECF, AST Wong, Lo RCL, Ng IOL, Yam JWP*. Nuclear Met promotes hepatocellular carcinoma tumorigenesis and metastasis by upregulation of TAK1 and activation of NF-κB pathway.  Cancer Letters 2017, 411:150-161.
  • Mao XW, Wong SYS, Tse EYT, Ko FCF, Tey SK, Yeung YS, Man K, Lo RCL, Ng IOL, Yam JWP*. Mechanisms through which hypoxia-induced caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma. Cancer Research 2016, 76(24): 7242-7253.
  • Ko FCF and Yam JWP*. Regulation of Deleted in Liver Cancer 1 tumor suppressor by protein-protein interactions and phosphorylation. International Journal of Cancer 2014, 135: 264-269.
  • Ko FCF, Chan LK, Sze KMF, Yeung YS, Tse EYT, Lu P, Yu MH, Ng IOL, Yam JWP*. PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis. Nature Communications 2013, 4: 1618. [Selected as featured article in NPG journals in cancer]
  • Chen L, Liu C, Ko FCF, Xu N, Ng IOL, Yam JWP*, Zhu G*. Solution structure of the PTB domain of human Tensin2 in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode. Journal of Biological Chemistry 2012, 287(31): 26104-26114.
  • Tse EYT, Ko FCF, Tung EKK, Chan LK, Lee TKW, Ngan ESW, Man K, Wong AST, Ng IOL, Yam JWP*. Caveolin-1 is overexpressed and associated with hepatocellular carcinoma tumorigenesis and metastasis. Journal of Pathology 2012, 226: 645-653.
  • Ko FCF, Chan LK, Tung EKK, Lowe SW, Ng IOL, Yam JWP*. Akt phosphorylation of Deleted in Liver Cancer 1 deregulates its suppression of liver cancer tumorigenesis and metastasis. Gastroenterology 2010, 139(4):1397-1407.
    • With editorial: Wuestefeld T, Zender L. DLC1 and liver cancer: the Akt connection. Gastroenterology 2010, 139(4): 1093-1096.
  • Ko FCF, Yeung YS, Wong CM, Chan LK, Poon RTP, Ng IOL, Yam JWP*. Deleted in liver cancer 1 isoforms are distinctly expressed in human tissues, functionally different and under differential transcriptional regulation. Liver International 2010, 30(1): 139-148.

Before 2010 (Selected)

  • Chan DW, Chan CY, Yam JWP, Ching YP, Ng IOL*. Prickle-1 negatively regulates wnt/beta-catenin pathway by promoting dishevelled ubiquitination/degradation in liver cancer. Gastroenterology 2006, 131:1218-1227.
  • Yam JWP, Ko FCF, Chan CY, Yau TO, Tung EKK, Leung THY, Jin DY, Ng IOL*. Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma. Hepatology 2006, 44:881-890.
  • Yam JWP, Ko FCF, Chan CY, Jin DY, Ng IOL*. Interaction of DLC1-tensin2 complex with caveolin-1 and implications in tumor suppression. Cancer Research 2006, 66:8367-8372.
  • Wong CM#, Yam JWP#, Ching YP, Yau TO, Leung HY, Jin DY, Ng IOL*. Rho GTPase activating protein DLC1 (deleted in liver cancer 1) suppresses cell proliferation and invasion in hepatocellular carcinoma. Cancer Research 2005, 65:8861-8868.
  • Leung THY, Ching YP, Yam JWP, Wong CM, Yau TO, Jin DY, Ng IOL*. Deleted in liver cancer 2, DLC2, suppresses cell transformation via inhibition of RhoA activity. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:15207-15212.
  • Yam JWP, Jin DY, So CW, Chan LC*. Identification and characterization of EBP, a novel EEN binding protein that inhibits ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. Blood 2004, 103:1445-1453.
  • Yam JWP, Chan KW, Hsiao WLW*. Transcriptional regulation of rat frizzled related protein gene promoter by CREB. Oncogene 2003, 22:3901-3910.
  • Yam JWP, Chan KW, Hsiao WLW*. Suppression of the tumorigenicity of mutant p53-transformed rat embryo fibroblasts through expression of a newly cloned rat nonmuscle myosin heavy chain-B. Oncogene 2001, 20:58-68.